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glisn skin. clinical age defense skincare

Key Ingredients

Our formulas are powered by advanced, clinically studied ingredients chosen to support the skin barrier, cell renewal, firmness, and hydration.

glisn retinol face serum

Retinol (Vitamin A)

• Boosts cell turnover for

smoother, firmer skin

• Reduces fine lines, acne, and

dark spots

• Encourages collagen synthesis

See Case Study

Vitamin c serum

Vitamin C

• Brightens dull complexion and

fades dark spots

• Neutralizes oxidative stress

• Stimulates collagen production

See Case Study

Glisn skin ferulic acid

Ferulic Acid

• Enhances stability of

Vitamin C and E

• Fights free radicals and

UV-induced skin aging

• Reduces inflammation and

protects the skin matrix

See Case Study

glisn skin orange stem cells, vitamin c stem cells serum

Orange Stem Cells

• Stimulate skin regeneration

and dermal density

• Reduce wrinkle depth and

improve firmness

• Restore skin structure at the

cellular level

See Case Study

glisn skin peptides

Peptides

• Stimulate collagen and

elastin production

• Help firm sagging skin

and reduce wrinkles

• Improve barrier function and

skin repair

See Case Study

glisn skin ceramides serum

Ceramides

• Strengthen and repair the

skin barrier

• Lock in moisture

and prevent dryness

• Soothe sensitivity and

inflammation

See Case Study

glisn skin antioxidant skincare

Antioxidants

• Protect against UV and

environmental stress

• Prevent premature aging

and collagen breakdown

• Brighten and even skin tone

See Case Study

glisn niacinamide toner- milky niacinamide

Niacinamide (Vitamin B3)

• Minimizes enlarged pores

and oiliness

• Brightens and evens out

skin tone

• Strengthens the skin barrier

• Anti-inflammatory for acne and rosacea

See Case Study

glisn hyaluronic acid serum, glisn skin

Hyaluronic Acid

• Deep hydration and plumping

• Improves elasticity and smooths

fine lines

• Works across all skin types

See Case Study

Retinol (Vitamin A)

Case Study:
A 12-week study using 0.1% retinol showed significant improvement in wrinkles, pigmentation, and skin renewal.
→ Kang et al., Archives of Dermatology, 2001 (PubMed)

*A fat-soluble vitamin and antioxidant derived from Vitamin A compounds

Vitamin c serum

Vitamin C

Case Study:
Daily use of 10% vitamin C cream improved wrinkles and roughness over 12 weeks.
→ Humbert et al., Experimental Dermatology, 2003

*A potent antioxidant essential for collagen synthesis

Glisn skin ferulic acid

Ferulic Acid

Case Study:

Adding 0.5% ferulic acid to a serum with vitamin C and vitamin E doubled protection against UV-induced erythema.

  • Reduced DNA damage and sunburn cell formation.
  • Improved antioxidant stability in formulations.

Lin et al., 2005 J Invest Dermatol, 125(4), 826–832.

Topical antioxidant solution with vitamins C, E, and ferulic acid protects human skin

  • Human trials showed significant protection against UV-induced redness and DNA damage.
  • Ferulic acid enhanced efficacy and stability of antioxidants.

Murray et al., 2008 J Am Acad Dermatol, 59(3), 418–425.

*A plant-based antioxidant found in rice bran, oats, and citrus fruits

glisn skin orange stem cells, vitamin c stem cells serum

Orange Stem Cells

Case Study:
A serum with orange stem cells reduced wrinkle depth and improved elasticity in 56 days.
→ Provital Group, Clinical Report, 2013

*Plant-derived stem cells from the orange fruit (Citrus sinensis)

glisn skin peptides

Peptides

Case Study:
Topical Matrixyl (palmitoyl pentapeptide) improved skin tone and reduced wrinkle depth within 4 weeks.
→ Robinson et al., International Journal of Cosmetic Science, 2005

*Short chains of amino acids, the building blocks of proteins like collagen and elastin

glisn skin ceramides serum

Ceramides

Case Study:
Review of ceramide function in the lipid barrier.

  • Key insight: Ceramides are critical for preventing water loss and protecting against irritants, allergens, and pathogens.

Madison, 2016 Journal of Investigative Dermatology, 136(12), 2310–2315.

Clinical benefit of ceramide-containing skin care in dry and aged skin. 

  • Studied elderly participants with dry skin using ceramide-enriched creams.
  • Findings: Increased stratum corneum ceramide levels, improved elasticity, and reduced transepidermal water loss (TEWL).
  • Conclusion: Ceramides are effective in combating dryness and age-related barrier decline.

Voegeli et al., 2007, International Journal of Cosmetic Science, 29(5), 411–418.

*Naturally occurring lipids (fats) that make up over 50% of the skin barrier

glisn skin antioxidant skincare

Antioxidants

Case Study:
A study evaluated the antioxidant and anti-inflammatory effects of topical superfruit extracts & key findings after regular topical use were: Significant reduction in oxidative stress markers, inhibition of collagen-degrading enzymes, protection against UV-induced skin damage and improved skin hydration and elasticity.

-Pacheco-Palencia, L. A., Talcott, S. T., & Safe, S. (2008) -Journal of Agricultural and Food Chemistry

*Molecules that neutralize free radicals and oxidative damage (Usually from Superfoods and Superfruits)

glisn niacinamide toner- milky niacinamide

Niacinamide (Vitamin B3)

Case Study:
4% niacinamide cream reduced dark spots and improved skin tone in melasma patients within 8 weeks.
→ Hakozaki et al., British Journal of Dermatology, 2002

*A water-soluble form of Vitamin B3

glisn hyaluronic acid serum, glisn skin

Hyaluronic Acid

Case Study:
HA-based serums significantly improved hydration and elasticity over 8 weeks.
→ Pavicic et al., Dermatologic Therapy, 2011

*A naturally occurring humectant that binds up to 1000x its weight in water

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glisn glycolic acid serums

Glycolic Acid (Alpha Hydroxy Acid)

• Deep exfoliation for brighter,

smoother skin

• Fades dark spots and

post-acne marks

• Stimulates collagen and elastin

See Case Study

glisn DMAE face serum

DMAE (Dimethylaminoethanol) 

• Firms and tones

• Reduces fine lines

• Anti-inflammatory

• Protects against free radicals

and oxidative stress.

See Case Study

glisn skin MSM serum

MSM (Methylsulfonylmethane) 

• Anti-inflammatory, helps

reduce redness, rosacea, and acne.

• Boosts collagen production,

Sulfur is a building block for collagen

and keratin.

• Improves skin texture

• Helps the skin retain moisture better.

See Case Study

Pomegranate

• Rich in Antioxidants

• Stimulate Collagen

• Brightens skin

• Skin Regeneration

• Skin Elasticity

See Case Study

glisn skin blueberries

Blueberries

• Potent Antioxidant

Protection

• Boosts Collagen &

Firmnes

• Evens Skin Tone

• Reduces Inflammation

• Supports Skin Barrier

See Case Study

glisn skin sake ferment

Sake Ferment

• Sebum production

• Skin brightness

• Pore size

• Skin texture (roughness)

See Case Study

glisn rice powder, daily facefoilant

Rice

• Gentle exfoliation

• Brightens & fades dark

spots

• Absorbs excess oils

• Refines pores

• Delivers Antioxidant Protections

See Case Study

glisn gotu kola

Gotu Kola

• Stimulates collagen Production

• Accelerates skin repair

and wounds

• Calms irritated skin

• Improves Skin Hydration

• Barrier Protection

• Antioxidant Protection

See Case Study

Stem Cell A: (Swiss Apple (Uttwiler Spätlauber)

• Cell regeneration

• Antiaging & Wrinkle reduction

• Firmness & Elasticity

• Improves Skin Tone

See Case Study

glisn glycolic acid serums

Glycolic Acid (Alpha Hydroxy Acid)

Case Study:

A 10% glycolic acid cream used daily improved tone, elasticity, and smoothness in photodamaged skin.
→ Smith et al., Dermatologic Surgery, 1996


 * Alpha hydroxy acids in skincare: a review of clinical studies. 

  • Findings: Increased epidermal thickness, smoother skin, and reduced hyperpigmentation.

Stiller et al., 1996, Journal of Dermatologic Surgery and Oncology, 22(6), 513–517.

*A small molecule AHA derived from sugarcane

glisn DMAE face serum

DMAE (Dimethylaminoethanol) 

Case Study:

A 2005 study published in the American Journal of Clinical Dermatology found significant improvements in forehead lines, under-eye circles, and lip shape with 3% DMAE gel.
→ Source: Am J Clin Dermatol. 2005

*A compound related to choline

glisn skin MSM serum

MSM (Methylsulfonylmethane) 

Case Study:

A 2008 clinical study found that MSM improved skin firmness, tone, and texture in just 8 weeks.
→ Source: J Int Soc Sports Nutr. 2008

*A sulfur-rich compound

Pomegranate

Case Study:

A controlled study of 28 women aged 40–65 used a topical cream containing 0.5% standardized pomegranate extract twice daily for 12 weeks. * Skin elasticity improved by 16% and wrinkle depth was reduced by 29% after 12 weeks.

-S. F. Hwang et al. Journal of Cosmetic Dermatology, 2013

glisn skin blueberries

Blueberries

Case Study:

Blueberry Extract in Skin Barrier Repair and Photoprotection. Findings: Blueberry-treated cells had significantly lower levels of oxidative stress after UV exposure. Collagen type I production increased, suggesting anti-aging and firming effects.

-Chen et al.  Oxidative Medicine and Cellular Longevity, 2019

glisn skin sake ferment

Sake Ferment

Case Study:

Twenty healthy Korean women applied a cream containing 97% Sake ferment filtrate to one half of their face twice daily for 4 weeks. The other half remained untreated as a control. Results After 4 Weeks: Sebum levels decreased by 64.17%, Pore size reduced by 15.66%, Skin brightness increased by 2.49% ,Skin texture improved by 16.47%

- Kim, H. J. et al. Asian Journal of Beauty and Cosmetology, 2014

*Scientists observed that sake brewers had unusually smooth, youthful hands and traced the benefit back to their daily contact with this fermented yeast.

glisn rice powder, daily facefoilant

Rice

Case Study:

Researchers applied a rice bran extract cream to the skin of 30 female volunteers with mild to moderate melasma. The treatment group applied the cream twice daily for 8 weeks.

Key Results: Melanin levels decreased by 19%, showing a clear skin-lightening effect. Skin hydration improved, likely due to the high lipid and vitamin E content.Participants reported visibly smoother and more radiant skin.

- Lee et al. Korean Journal of Cosmetic Science, 2013

*Conclusion:

Rice bran-based products, including rice powder and extract, offer a natural solution for skin brightening, exfoliation, and antioxidant defense. The study supported rice powder’s effectiveness in improving pigmentation and texture without irritation.

glisn gotu kola

Gotu Kola

Case Study:

Twenty subjects with visible signs of photoaging applied a cream containing 5% Gotu Kola (Centella asiatica) extract to one half of the face, twice daily, for 6 months. The other half remained untreated as a control.

Results: Skin elasticity improved by 25%, Visible wrinkle depth reduced by 19%, Hydration increased significantly on the treated side compared to baseline, No irritation or adverse effects were reported.

-L. Tenni et al.  International Journal of Cosmetic Science, 2008

Conclusion:

The study confirmed Gotu kola’s effectiveness as a safe and potent ingredient for firming skin, reducing wrinkles, and supporting long-term skin barrier health. Researchers credited triterpenoids with enhancing dermal structure and collagen quality.

Stem Cell A: (Swiss Apple (Uttwiler Spätlauber)

Case Studies:

By: Mibelle Biochemistry (Switzerland).

A cream containing 2% stem cell extract was applied to the crow’s feet area of 20 participants (ages 37–64) twice daily for 28 days.

Results: Skin stem cells showed a significant increase in longevity and vitality.Participants saw a reduction in wrinkle depth of up to 15% after four weeks. Improved epidermal regeneration, firmness, and hydration were observed.

By: Journal of Cosmetic Dermatology (2014)

A Study of 32 healthy female volunteers aged 35–65. A 8-week trial using a cream with 2% stem cell A extract

Findings: Statistically significant improvement in skin elasticity and firmness, Reduction in fine lines and increased hydration. No adverse reactions observed, confirming the ingredient’s skin compatibility

Consumer Clinical Trials- Manufacturer sponsored

Several brands using Apple Stem Cell A (PhytoCellTec™) in their anti-aging serums reported similar anecdotal and consumer-based evidence:

  • 70% reported visibly firmer skin in 4 weeks
  • 65% saw reduced crow’s feet and fine lines
  • Consumer satisfaction > 85% when used in combination with peptides and hyaluronic acid

Conclusion: Apple stem cell extract improved overall skin quality and reduced visible signs of aging, supporting its use in anti-aging skincare.

*The stem cell extract not only protected skin stem cells from UV-induced damage but also stimulated skin regeneration and visibly reduced wrinkles.

References

  1. Mibelle Biochemistry, PhytoCellTec™ Malus Domestica White Paper.
  2. Gharavi et al., Journal of Cosmetic Dermatology (2014).
  3. US Patent 7,838,042 B2 – “Plant cell cultures for cosmetic use”.
  4. Mibelle Biochemistry. (2008). Technical Data Sheet on Malus Domestica.
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